HMOX1 and Alzheimer disease: Although there are currently only a few reports on the treatment of AD with polyphenols with this target, studies have already shown that tea polyphenols reverse the upregulation of MST1/2 in RAW264.7 cells after H2O2 application, inhibit oxidative stress through the MST/Nrf2 axis, and Keap1/Nrf2/HO-1 signaling pathways, and reduce the production of ROS, the release of NO, and the level of MDA in cells [268].