In addition, genistein and curcumin have also been identified as RTK inhibitors, which cause EGFR tyrosine phosphorylation and inhibition of EGFR downstream signaling molecules Akt, ERK1/2, and STAT3 in oral squamous cell carcinoma, thus exhibiting potent cancer chemopreventive activity [112]. The gene discussed is EGFR; the disease is oral cavity squamous cell carcinoma.