HMOX1 and hepatocellular carcinoma: Moreover, synergistic effects were observed in combination with I3C and SFN or PEITC in a human liver hepatoma cell line (HepG2-C8), leading to the induction of endogenous Nrf2, phase II genes (GSTm2, UGT1A1 and NQO1) and antioxidant genes (HO-1 and SOD1), which could ultimately enhance cancer chemopreventive activity [120].