ABCC10 and obesity due to melanocortin 4 receptor deficiency: Similarly, we observed an increase in the body weight in high-fat obesity-diet-fed Abcc10−/− (HFD-Abcc10−/−) mice compared to CD-Abcc10+/+ mice, but this increase was lower than in the HFD-Abcc10+/+ mice (Figure 2A).