ABCC10 and obesity due to melanocortin 4 receptor deficiency: As expected, there was a significant increase in body weight in high-fat obesity-diet-fed Abcc10+/+ (HFD-Abcc10+/+) mice over the period of 16 weeks as compared to chow-fed Abcc10+/+ (CD-Abcc10+/+) mice (Figure 2A).