TNF and Fever: We found that LPS treatment could significantly increase the rectal temperature (Figure 1A) and dorsal interscapular surface temperature (Figure 1B,C) (contribute to fever) of mice, and the mRNA levels of TNFα, IL-6, Ucp1, and Pgc1α in the BAT, but did not affect the expression of Cpt1α and Cidea (Figure 1D,E).