Recently, there have been reports on several molecular targets in the pathophysiology of migraine such as calcitonin gene-related peptide (CGRP), pituitary adenylate cyclase-activating peptide (PACAP), nitric oxide (NO), transient receptor potential cation channel subfamily vanilloid 1 (TRPV1), and transient receptor potential cation channel subfamily melastatin 8 (TRPM8) [15,16]. This evidence concerns the gene TRPM8 and migraine disorder.