AKT1 and Other metabolic disease: Several studies have reported that common components (such as luteolin, baicalin, apigenin-7-O-glucoside and naringenin-7-O-glucoside) as well as unique components (such as naringenin, taxifolin-7-O-glucoside, apigenin and acacetin-7-O-glucoside) in CMF and CIF confer antihypertensive, antioxidant, anti-inflammatory and antiviral properties through regulating NF-κB and PI3K-Akt signaling pathways, as well as RAS and metabolic disorders [27,28,29,30,31,32].