TNF and cancer: Subsequent GO enrichment and KEGG pathway analyses showed that the anti-LFHSH mechanisms of CMF and CIF were mainly associated with the regulation of PI3K activity, Akt viability, NF-κB activity, the inflammatory response, the response to interleukin-1 and other biological processes as well as cancer, lipid and atherosclerosis, TNF signaling, T-cell receptor signaling, antifolate resistance, and other pathways (Figure 2A,B).