A single-arm phase II trial of apatinib plus anti-PD1 camrelizumab (APFAO) in 43 patients with OS showed an ORR of 20.9% and a 6-month PFS of 50.9%, with a statistically longer PFS in patients with a programmed cell death 1 ligand-1 (PD-L1) tumor proportion score ≥ 5% (p = 0.004) [86]. The gene discussed is CD274; the disease is neoplasm.