The results here presented add new scientific evidence of an association between specific LTA and SOD1/SOD2 genotypes and the development of focal migraine-related visible WMHs, thus supporting the view that an imbalance between pro-inflammatory/pro-oxidative and antioxidant events in genetically predisposed individuals may influence the presence of WMHs, possibly conferring an increased risk of developing cerebrovascular accidents. The gene discussed is SOD1; the disease is migraine disorder.