In a previous study on 97 Turkish children and adolescents, Saygi and colleagues observed the presence of a significant correlation between SOD2 rs4880 TT genotype and disease [44], a finding that could not be fully reproduced in a subsequent study by Palmirotta et al., who suggested that SOD2 may act as a disease-modifier gene influencing oxidative mechanisms in migraine, based on the finding of an association between SOD2 Ala16Val polymorphism and the occurrence of UAs during the attack in MWA [25]. The gene discussed is SOD2; the disease is migraine disorder.