CIN affects genes located in focal amplification areas (e.g., CNNE1, MYC, and MECOM) and focal deletion areas (e.g., PTEN, RB1, and NF1) [82,172]; consequently, patients harboring these aberrations usually evade therapy and display tumor recurrence, as occurs for CNNE1 amplification [222] or PTEN loss [223]. The gene discussed is PTEN; the disease is neoplasm.