Other strategies based on the Risk of Ovarian Cancer Algorithm (ROCA) [51] aimed to stratify risk according to CA125 levels; however, the use of ROCA in the Normal Risk Ovarian Screening Study (NROSS) [52] or the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) [53] clinical trials failed to suffice for the early detection of OC due to a high number of false positives and the associated failure to reduce HGSOC-associated mortality rates [14,54]. This evidence concerns the gene MUC16 and ovarian cancer.