Within one comprehensive data set, we use genetic, transcriptomic and MRI data of 1949 participants from the Study of Health in Pomerania (SHIP) [31] to reinvestigate the association of the expression level and missense variant of TREML2 with (a) the WMH volume and (b) an AD score, a machine learning-generated MRI-based pre-symptomatic score measuring the resemblance of an individual’s brain atrophy with those of clinical AD cases. This evidence concerns the gene TREML2 and Brain atrophy.