Assuming a positive effect direction, because the APOE ε4 allele is known to increase the AD risk, and thus using a one-sided significance level of 0.10 we did see a significant direct association between APOE ε4 and the AD score (β = 0.11, 95% CI = [−0.0049; 0.22], p = 0.061, N = 1861 in the base model; β = 0.11, 95% CI = [−0.0012; 0.23], p = 0.052, N = 1861 in the full model). The gene discussed is APOE; the disease is Alzheimer disease.