TREML2 and cerebral small vessel disease: This is supported by the fact that Mishra et al. [36] found no association between rs3747742 and extremes of cerebral small vessel disease (measured via WMH volume and presence of lacunes) in a genomic meta-analysis of more than 10,000 participants of European ancestry, in which SHIP-TREND-0 was included, and by the fact that rs3747742 has not been observed to be an eQTL of TREML2 and we also found no association with TREML2 expression in whole-blood.