Zhang and his colleagues also described that HSF2 may be involved in thyroid carcinoma development by regulating FosB [111], Fos is the one of transcription factor families and this Fos family includes c-Fos (the human homologue of retroviral oncogene v-Fos), FosB, Fra-1 and Fra-2 as well as smaller FosB splicing variants FosB2 and deltaFosB2 [120]. Here, FOSB is linked to thyroid gland carcinoma.