Pierrefiche and her colleagues previously showed in two EtOH binge-like episodes in young adult rats that (1) the LTD through the NMDA receptor is selectively blocked in hippocampal slices; (2) the NMDA receptor sensitivity to a GluN2B (NR2B) subunit antagonist is increased; and (3) cognitive deficits are induced [180]. Here, GRIN2B is linked to Cognitive impairment.