Other studies showed that CatK induced platelet aggregation by the up-regulation of sonic hedgehog (SHH), parathyroid hormone-related protein (PTHrP), osteopontin (OPN), and TGFβ in epithelial–mesenchymal-like cells from patients with Luminal B breast cancer [88]. The gene discussed is PTHLH; the disease is luminal B breast carcinoma.