SLC5A2 and hydrops fetalis: In the dedicated HF-focused EMPEROR-Reduced and Empagliflozin Outcome Trial in Patients with Chronic Heart failure with Preserved Ejection Fraction (EMPEROR-Preserved) [64,65], SGLT2 inhibitors reduced kidney outcomes and the risk of hospitalization, due to HF in patients with both HF with preserved ejection (HFpEF) and HFrEF.