Forty-seven patients developed SAIs, including 15 lower respiratory tract infections (LRTIs) and 20 UTIs, two flu-like infections, one erysipelas, one locally infected leg ulcer, one genital candida infection, one gastroenteritis caused by the norovirus, one cholecystitis and five systemic infections without a clear origin, defined by the systemically elevated inflammation mediators, such as CRP > 30 mg/L and/or white blood cell count (WBC) > 11.000/μL in combination with the clinical symptoms, such as fever. The gene discussed is CRP; the disease is erysipelas.