Interestingly, it was shown that neutrophil serine proteinases NE, CG and PR3 are IGFBP-3 specific proteases and further shown that there is a positive correlation among IGFBP-3 proteolysis, neutrophil serine proteinase activity, and chronic inflammatory manifestation such as insulin resistance, BMI, TNF-α and IL-8 [33,34,35]. The gene discussed is IGFBP3; the disease is Insulin resistance.