Insulin-like growth factor binding protein-3 (IGFBP-3), a major IGFBP species in circulation, has been demonstrated to have not only direct antitumor functions in human cancers but also anti-inflammatory properties in normal cells through the activation of a specific receptor, IGFBP-3R [22,23,24,25,26]. The gene discussed is IGFBP3; the disease is cancer.