SERPINA1 and adenocarcinoma: Furthermore, microscopic analysis using hematoxylin/eosin stained tissue clearly demonstrates that AAT administration significantly reduced colonic inflammation, mucosa expansion, inflammatory cell infiltration, muscle thickening and intramucosal adenocarcinoma (TIS) formation compared with PBS-treated controls in early stage (total 47 days, Figure 1G) as well as at a later stage (total 91 days, Figure 1H).