This multicomponent system comprised a gold core, cytokines IL-12 and/or TNF, and DOX. The synergistic effect was explained by affected endothelial permeability due to the isoDRG-peptide integrin-mediated uptake, and consequential reduction in drug penetration barriers. Presence of the cytokines was to trigger a reaction from immunocompetent cells directed towards the tumor. The results suggest that the displayed TNF played a more important role in the studied tumor inhibition than the displayed IL-12. The gene discussed is TNF; the disease is neoplasm.