Among the proteins involved in the immune function within the tumor microenvironment (Figure 5A), five exhibited an increase, including histidine-rich glycoprotein (encoded by Hrg), interleukin-33 (encoded by Il33), CD276 antigen (encoded by Cd276), leucine-rich repeat flightless-interacting protein 1 (encoded by Lrrfip1) and pro-low-density lipoprotein receptor-related protein 1 (encoded by Lrp1). The gene discussed is LRRFIP1; the disease is neoplasm.