Further, the association of PAD-mediated citrullination of fibronectin, an important constituent of ECM, with CVDs, fibrosis, carcinogenesis, rheumatoid arthritis, alteration of integrin clustering, and focal adhesion stability suggests its role in regulating vascular remodeling because fibronectin-mediated inflammatory signaling through integrin α5 is important for vascular remodeling [212,213,214]. This evidence concerns the gene FN1 and peripheral arterial disease.