It should be noted that despite the fact that the rs117585797 ANO2 polymorphism, together with the rs11031002 and rs11031005 polymorphisms, is part of the most significant models of intergenic interactions associated with endometriosis, as a result of bioinformatic analysis (using Gene Ontology and GeneMANIA software), we have not revealed convincing evidence of the exact mechanisms of these interactions. This evidence concerns the gene ANO2 and endometriosis.