Genotypes epistasis interaction such as rs11031002 FSHB TA × rs112295236 SLC22A10 CC × rs11031005 FSHB TT and rs11031002 FSHB TA × rs117585797 ANO2 CC × rs112295236 SLC22A10 CC × rs11031005 FSHB TT showed the most substantial protective effects on endometriosis risk (for both beta coefficients equal to −3.35, p = 0.000006) (Supplementary Table S2). This evidence concerns the gene ANO2 and endometriosis.