Numerous GWAS data confirm the importance of the FSHB promoter region SNP rs11031006 for several female reproductive outcomes including age at menarche [31] and menopause [32]; menstrual cycle parameters (menstrual cycle length and excessive, frequent and irregular menstruation) and bilateral oophorectomy [33]; dizygotic twinning and FSH concentration [34]; uterine fibroids [35]; and PCOS, FSH and LH concentrations [36,37]. This evidence concerns the gene BRD2 and polycystic ovary syndrome.