For instance, several SNPs such as rs34670419 ZKSCAN5, rs11031002 and rs11031005 FSHB, rs112295236 SLC22A10, rs727428 SHBG, and rs1641549 TP53 are associated with gene expression changes in whole blood (ZKSCAN5, TNFSF12, FXR2, TNFSF13), thyroid (GS1-259H13.2, ARL14EP, ARL14EP, EFNB3), pituitary (SHBG), adipose (ARL14EP, CYP3A7, EFNB3), adrenal gland (CYP3A7), etc., thereby demonstrating their putative pathobiology involvement in endometriosis. The gene discussed is SHBG; the disease is endometriosis.