In another study, Puissant et al. [129] reported that resveratrol induces autophagy in imatinib-sensitive (IM-S) and imatinib-resistant (IM-R) K562 chronic myeloid leukemia cells through JNK-dependent accumulation of p62. Here, MAPK8 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.