CircSMARCA5 is also functionally linked to miRNAs 126-3p, 515-5p and their targets; indeed, similar to circSMARCA5 [21,22,23], miR-126-3p and its target IGFBP2 are involved in GBM progression, by regulating cell migration, invasion [45,88,89,90], and angiogenesis [91,92]. Here, IGFBP2 is linked to glioblastoma.