Collectively, our data suggest circSMARCA5 as an upstream regulator of the expression of TS miRNAs 126-3p and 515-5p and their downstream targets IGFBP2 and NRAS mRNA in GBM cells, extending our knowledge on the disrupted tumor suppressive pathways mediated by circSMARCA5 in GBM cells. The gene discussed is IGFBP2; the disease is glioblastoma.