RSF1 is an essential interphase centromere protein that maintains chromosome stability and protein homeostasis but also has roles in DSB and transcription regulator functions through its interactions with HDAC1, CENP-A, ATM, SNF2H, cyclin E1, CBP, NF-κB, BubR1, and many other cancer-related proteins [105]. The gene discussed is RSF1; the disease is cancer.