In NAFL/NASH patients, there is an increase in SREBP-2 expression; its overexpression is not found in obese patients or patients with other liver diseases, such as hepatitis C. SREBP-2 may be activated in NAFL/NASH by an additional molecular pathway that is responsible for the increase in hepatic free cholesterol levels, but it is independent of the pathway related to changes in cellular cholesterol [50]. This evidence concerns the gene SREBF2 and liver disorder.