miR-34a has an important role in NAFLD development: it is involved in the dysregulation of cholesterol metabolism because it causes the suppression of sirtuin 1 (encoded by SIRT1), a molecule that is responsible for the regulation of AMP kinase (AMPK) activity, which regulates HMGCR phosphorylation [51,52]. The gene discussed is SIRT1; the disease is metabolic dysfunction-associated steatotic liver disease.