Pathogenic variants in TRIP12 (Thyroid Hormone Receptor Interactor 12; OMIM #604506), located on chromosome 2q36.3, result in an autosomal dominant neurodevelopmental disorder termed Clark–Baraitser syndrome (OMIM #617752) [1]; additionally, TRIP12 is one of the primary genes linked to intellectual disability (ID) [2]. Here, TRIP12 is linked to Intellectual disability.