Figure 1 shows the first PLS model which examined the associations between the DisQoL phenomenome (an LV extracted from the four HR-QoL and three Sheehan domains) as the final outcome variable and input variables including education, magnesium, calcium, IL-6 and IL-23 (entered as single indicators), the Th17-TNF axis (an LV extracted from IL-17, IL-1β, IL-21, IL-22 and TNF-α), the G-CoDe (an LV extracted from the BACs test results), and the symptomatome (an LV extracted from the negative PANSS score, the total SDS score, the SANS items and total score, PHEM symptoms, PMR and FTD). This evidence concerns the gene IL6 and frontotemporal dementia.