A significantly lower risk of invasive mechanical ventilation was observed in SU users than in nonusers in the female and male sex, age 50 to 80 years, no obesity, with or without smoking, CCI = 0 or ≥2, DCSI 0–≥2, OAD numbers = 0–3, with or without insulin use (Table S5). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.