TNF and cancer: Furthermore, a comparison of ADIPOR and TNF-α mRNA levels between malignantly changed and healthy tissue revealed lower ADIPOR2 mRNA levels in cancer (p < 0.0001, Figure 3c) as well as lower TNF-α gene expression (p < 0.0026, Figure 3e), while ADIPOR1 levels did not differ between the groups (p = 0.9747, Figure 3a).