This link between PCOS, miscarriage, and LH hypersecretion, however, began to be thrown into doubt when a subsequent study in which raised LH levels were suppressed before pregnancy in a randomized controlled trial of 106 women with a history of three or more consecutive first trimester miscarriages, polycystic ovaries, and hypersecretion of LH did not find an improvement in pregnancy outcome [35]. This evidence concerns the gene PLOD1 and polycystic ovary syndrome.