Many studies have suggested that hyperinsulinemia, which is present in PCOS, is the main pathogenic mechanism of hypertension in pregnancy, as the vascular endothelial cells which are insulin-sensitive are activated due to this state of hyperinsulinemia, causing a decreased production of prostaglandin, and thereby increasing the peripheral vascular resistance leading to an increase in the blood pressure [66]. Here, INS is linked to hyperinsulinism.