On the other hand, a pilot study by Seefried et al. in 2017 [52] observed no significant decline in CRP levels in individuals with end-stage renal disease (i.e., hemodialysis patients) using frequencies of 14–28 Hz along with other exercises, twice weekly for 12 weeks, before or after hemodialysis sessions. This evidence concerns the gene CRP and stage 5 chronic kidney disease.