IGHE and Allergy: Although high levels of IL-6 have been found in patients with food allergies [27] and it has been shown that IL-6 can promote intestinal barrier permeability [28] and the suppression of regulatory T-cell generation [29], IL-8 promotes the recruitment of neutrophils and basophils to inflammation sites and is produced by IgE-binding monocytes in animals with naturally occurring allergies [30].