IRS2 and Hypoglycemia: Low molecular weight (4.8 kDa) sulfated polysaccharides from Enteromorpha prolifera was shown to protect against hypoglycemia by modulating the gene expression of glycogen synthase kinase 3 (GSK-3), insulin receptors, insulin receptor substrate 2 (IRS-2), protein kinase B (PKB), and phosphatidylinositol 3 kinase (PI3K) [30].