miR-338-5-p and miR-421 have been shown to be downregulated in SPINK1+ subtype of prostate cancer (2-fold and 1-4-fold as compared to ERG+ subtype, respectively) and negatively regulate proliferation, invasion, and colony and foci formation ability in SPINK1+ cell line. The gene discussed is SPINK1; the disease is Familial prostate cancer.