Similarly, a combination of bazedoxifene and SCH527123 (inhibitor of C-X-C motif chemokine receptors; Il-8 receptors) synergically repressed STAT3 and Akt phosphorylation in ovarian cancer cells (OVCAR3, SKOV3, and CAOV3) and in mice bearing CAOV3 tumours when compared to agents inhibiting just IL-6 or IL-8 [123]. This evidence concerns the gene STAT3 and ovarian cancer.