Due to the overexpression of CD30 and the similarity to inflammatory diseases, it is extremely important to make a correct diagnosis to perform a differential diagnosis in order to exclude diseases such as HD, lichen dandruff, primary cutaneous ALCL, mycosis fungoides (MF), CTCL, and other mild conditions such as atopic dermatitis, viral infections, scabies, mycobacterial infections, and drug reactions [12,15,16,17,18]. This evidence concerns the gene TNFRSF8 and Huntington disease.