Most often, diagnostics are conducted to exclude lymphoproliferative diseases expressing CD30+, the vast majority of which are various types of lymphomas (primary cutaneous anaplastic large cell lymphoma, secondary skin lesions of systemic anaplastic large cell lymphoma, or Hodgkin lymphoma) (Figure 3) [93,94,95,96]. This evidence concerns the gene TNFRSF8 and Hodgkins lymphoma.