Here, we investigated the role of autophagy in the initiation and progression of epithelial skin tumors by ablating Atg7 in two mouse models of skin cancer (Figure 1 [22]): DMBA/TPA-mediated two-stage carcinogenesis and genetically driven carcinogenesis in the K5-SOS EGFRwa2/wa2 model [22]. The gene discussed is ATG7; the disease is skin cancer.