The mean tumor volume was significantly larger in the fully autophagy-competent mice (K5-SOS EGFRwa2/wa2 Atg7f/f) than in mice lacking Atg7 in epithelial cells (K5-SOS EGFRwa2/wa2 Atg7Δep) from week 4 until week 12 (Figure 3A). This evidence concerns the gene ATG7 and neoplasm.