RUNX1 plays an important role in the development of the hematopoietic system and its mutations lead to the occurrence of hematological malignancies, such as acute myeloid leukemia (AML), acute lymphoid leukemia (ALL), and familial platelet disorder with a predisposition to acute myeloid leukemia (FPD/AML) [2,47,48,59,60,61]. Here, RUNX1 is linked to hematologic disorder.