Recently, our study showed that cells with activated Wnt signaling and EMT program showed higher RUNX2 expression in a heterogeneous colorectal cancer cell population and that overexpression of RUNX2 enhanced cell migration in colon cancer cells, as well as in many other cancer cells, including bladder, glioma, cervical, liver, and lung cancers [19]. This evidence concerns the gene RUNX2 and central nervous system cancer.