RUNX1 and leukemia: In leukemia cell lines HL60 and Jurkat, and CD34+ progenitor cells, induction of the Wnt/β-catenin signal increases the expression of the RUNX1 P1 isoform, which may be critical for leukemia onset and progression [100]; in colon cancer cells, RUNX2 was found to be upregulated by the same pathway [19].