LDHA and colorectal carcinoma: Moreover, gene variants of ADH have sex-dependent effects where the risk of distal CRC increases only in male drinkers having ADH1B rs4147536 SNP in the ADH1B gene, and the risk of proximal CRC increases in female drinkers having ADH1C rs283415 SNP in the ADH1C gene, whereas gene variant ALDH2 rs671 in the ALDH gene slows the oxidation of acetaldehyde to acetate with no reported sex-dependent effects [45].