ZNF746 and Parkinson disease: To investigate whether SNO-PARIS plays a role in the α-syn PFFs-induced PD model, we stereotaxically injected both α-syn PFFs and lentiviruses overexpressing PARIS WT, C265S, or C265W into the STR and SN of 2-months-old C57BL/6 mice, respectively (Figure 6a).