Focusing on the adjuvanticity of dying cancer cells, it has been recently accepted that chemokine expression, like other immunostimulatory signals such as the extracellular ATP release (find-me signal), calreticulin exposure (eat-me signal) and HMGB1 release, has a key role occurring in this narrow and complex communication between cells which is needed to obtain an efficient recruitment of APCs and to prime a cytotoxic lymphocyte (CTL)-dependent immune response. This evidence concerns the gene HMGB1 and cancer.