Hoshi et al. found that MUC5Ac may inhibit neutrophil-mediated antitumor effects by mediating the immune escape of tumor cells, then they investigated the effect of MUC5Ac on TRAIL-mediated apoptosis and found that MUC5Ac inhibited TRAIL-induced apoptosis in human pancreatic cancer cells [74]. This evidence concerns the gene TNFSF10 and pancreatic neoplasm.