Dong et al. found that C1GALT1 promoted gastric cancer cell proliferation, migration, and invasion by regulating the O-glycosylation of integrin α5, and thus activated the PI3K/AKT pathway, identified integrin α5 as a novel downstream target of C1GALT1 by lectin pull-down assay and mass spectrometry analysis in gastric cancer [99]. Here, AKT1 is linked to gastric cancer.