Multiple genes in the semaphorin pathway (SEMA3A, SEMA3C), plexin and neuropilin receptors (PLXNA1, PLXNA2, PLXNB2, PLXND1) and downstream genes (FARP1, FARP2), known to activate RAC1 and FLNA, promoting invasion and metastasis, were also upregulated, some of which have been associated with pancreatic cancer and poor survival [38]. This evidence concerns the gene PLXND1 and pancreatic neoplasm.