This included elements of the Hedgehog signaling pathway (SHH, GAS1), semaphorin signaling (SEMA3A, PLXNA1, PLXNB2, PLXND1, PLXNA2, FARP1, FARP2) and also axon guidance pathways (ROBO1, SLIT1, SLIT3 and SLITRK2), all notable for their involvement in pancreatic cancer progression and metastasis [29,30,31] (Figure 2k). Here, SHH is linked to familial pancreatic carcinoma.