This included elements of the Hedgehog signaling pathway (SHH, GAS1), semaphorin signaling (SEMA3A, PLXNA1, PLXNB2, PLXND1, PLXNA2, FARP1, FARP2) and also axon guidance pathways (ROBO1, SLIT1, SLIT3 and SLITRK2), all notable for their involvement in pancreatic cancer progression and metastasis [29,30,31] (Figure 2k). The gene discussed is ROBO1; the disease is familial pancreatic carcinoma.