Multiple genes in the semaphorin pathway (SEMA3A, SEMA3C), plexin and neuropilin receptors (PLXNA1, PLXNA2, PLXNB2, PLXND1) and downstream genes (FARP1, FARP2), known to activate RAC1 and FLNA, promoting invasion and metastasis, were also upregulated, some of which have been associated with pancreatic cancer and poor survival [38]. Here, PLXNA1 is linked to familial pancreatic carcinoma.