Along with TNFSF14, LAIR1, NECTIN2, TNFRSF12A, HHLA2, and TNFSF4, TNFSF15 was found to be significantly linked and adversely associated with age in ccRCC patients in TCGA and GEO datasets. The gene discussed is TNFSF15; the disease is nonpapillary renal cell carcinoma.