NFKB1 and pneumonia: Zhang et al. [81] found that knockdown of lncRNA XIST inhibited the expression of TLR4 by targeting miR-370-3p, thereby regulating the JAK/STAT3 and NF-κB signaling pathways, inhibiting cellular apoptosis and the secretion level of inflammatory cytokines, and reducing LPS-induced cell damage; this process may be used to develop a strategy for treating acute pneumonia (Figure 6).