The mutual inhibition of caspase 8 and RIPK3 is essential for the development of NASH and hepatocarcinogenesis [64,94], and RIPK3 prevents cell proliferation from limiting the development of HCCs by inhibiting caspase 8 cleavage and JNK activation [64]. The gene discussed is CASP8; the disease is metabolic dysfunction-associated steatohepatitis.