Earlier studies also confirmed modest activation of the glomerular NF-κB signaling pathway in streptozotocin treated rats as early as one month after the induction of diabetes [81], while in patients with type 2 diabetes, NF-κB activation was mainly detected in cortical tubular epithelial cells and, to a lesser extent, in some glomeruli [82]. This evidence concerns the gene NFKB1 and diabetes mellitus.