Similar, reduced PINK1/Parkin mitophagy was reported under high glucose conditions in HK-2 cells and in the streptozotocin-induced mouse model of DKD [10,126,127], in proximal tubular cells [122] and in podocytes and db/db mouse model of DKD [128] and in rats on a high fat diet [129]. This evidence concerns the gene PRKN and diabetic kidney disease.