Most recently, novel ADNP syndrome mice have been developed using CRISPER-Cas9 gene editing technology to produce mice heterozygous for Adnp pTyr718* (Tyr), a paralog of the most common ADNP mutation, which have Tyr-specific sex differences. The gene discussed is ADNP; the disease is ADNP-related multiple congenital anomalies - intellectual disability - autism spectrum disorder.