Additional studies of ADNP’s protein sequence revealed the SH3-binding domain for SHANK3 (previously discussed in Section 6.1.1 to account for 1–2% of all ASD patients and for Phelan-McDermid Syndrome) and also actin-binding domains, suggesting possible shared underlying mechanisms for disease dysfunction [93]. Here, SHANK3 is linked to Monosomy 22q13.