Across all eight PDXs, we confirmed the presence of common PCa-associated genomic alterations [3,4,43], including losses and gains of TP53, PTEN, RB1 and MYC as well as large chromosomal aberrations on 8p, 8q, 10q, 13q, 16q, 17p and 18q (Figure 2C). The gene discussed is TP53; the disease is posterior cortical atrophy.