PTEN and posterior cortical atrophy: Across all eight PDXs, we confirmed the presence of common PCa-associated genomic alterations [3,4,43], including losses and gains of TP53, PTEN, RB1 and MYC as well as large chromosomal aberrations on 8p, 8q, 10q, 13q, 16q, 17p and 18q (Figure 2C).