TCF3 and Huntington disease: The upregulation of the gene target of the Wnt/β-catenin pathway was observed also by Lim et al. This team showed that components of the pathway are upregulated in iPSC-derived brain microvascular endothelial cells from HD patients, including ligands (WNT-3, -4, -6, -7B, and -10A), effectors (TCF3 and TCF4), and downstream targets (AXIN2 and APDCC1) [128].