TCF3 and Huntington disease: Smith-Geater et al. showed, in HD neuronal cells derived from iPSCs, a significant dysregulation of several members of the pathway, including the downregulation of the components of the β-catenin destruction complex and the increased expression of Transcription Factor 3 (TF3) and frizzled transcripts, as well as the increased expression of Wnt transcriptional targets such as CCND1 [129].