Figure 1A shows dot blot analysis of human soluble PBS fractions probed with OC, A11, 6E10 and 4G8 antibodies. OC positive oligomers, but not A11, 6E10 nor 4G8 immunoreactivity, was increased in AD brain samples compare to normal samples. In Figure 1B, a comprehensive plot shows the calculated fold changes in immunoreactivity to each antibody. Here, BGLAP is linked to Alzheimer disease.